Objective To explore the application efficacy of personalized exercise rehabilitation on patients after coronary intervention. Methods A total of 130 patients who underwent coronary intervention in our hospital from January 2022 to January 2023 were recruited in this study. They were randomly divided into control group (n=65, routine rehabilitation intervention) and observation group (n=65, personalized exercise rehabilitation intervention). Cardiac function, exercise endurance, muscle strength and balance function, quality of life and major adverse cardiovascular events (MACE) before intervention and in three months after surgery were compared between the two groups. SPSS statistics 22.0 was used for data analysis. Data comparison between two groups was performed using student′s t test or Chi-square test depending on data type. Results The observation group had significantly higher left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), cardiac output (CO), 6-minute walk test (6MWT), one-repetition maximum (1-RM), Berg balance scale (BBS) score, scores of short form 36-item health survey (SF-36), and activities of daily living (ADL), and lower left ventricular end-diastolic diameter (LVEDD) and interventricular septum thickness (IVST) when compared with the control group (P<0.05). The incidence of MACE was statistically lower in the observation group than the control group (7.69% vs 20.00%, P<0.05). Conclusion Personalized exercise prescription can improve cardiac function, enhance exercise endurance, muscle strength and balance function, promote quality of life, and reduce the incidence of MACE in patients after coronary intervention.