Objective To analyze the influencing factors for decreased quality of life in elderly patients with chronic vaginitis. Methods A total of 100 elderly patients with chronic vaginitis admitted to our department from January 2020 to January 2022 were selected as the vaginitis group, and another 100 healthy elderly individuals undergoing physical examinations simultaneously in our hospital were enrolled as the control group. According to the results of quality of life scale, the patients with chronic vaginitis were divided into normal life quality group (n=60) and declining life quality group (n=40). Their clinical data were compared between the groups and subgroups. SPSS statistics 20.0 was used for data analysis. According to the data type, t test orχ² test was used for data comparison between groups. Multivariate logistic regression analysis was used to analyze the influencing factors for declining quality of life. Results The scores in physical health, psychological health, social relationships, and environmental health domains were significantly lower in the vaginitis group than the control group (P<0.05). The patients from the declining quality of life group had longer course of vaginitis, more severe vaginitis, more comorbid chronic diseases, and larger proportion of declining intrinsic capacity, but lower ratio of regular physical activity than the patients in the normal quality of life group (P<0.05). Multivariate logistic regression analysis showed that duration of vaginitis (OR=2.718, 95%CI 1.988-3.723; P<0.001), severity of vaginitis (OR=1.949, 95%CI 1.195-3.182; P=0.007), comorbid chronic diseases (OR=1.988, 95%CI 1.199-3.293; P=0.008), and decline in intrinsic capacity (OR=2.895, 95%CI 1.342-6.246; P=0.007) were independent risk factors, and regular physical activity was an independent protective factor (OR=0.744, 95%CI 0.363-1.526; P=0.001) for declining quality of life of elderly patients with chronic vaginal inflammation. Conclusion The duration of vaginitis, severity of vaginitis, comorbid chronic diseases and decline in IC were independent risk factors. Risk factors should be screened as early as possible, and then active preventive interventions should be implemented.