Sarcopenia, the age-related loss of muscle mass and functions, increases the risk of falls, fractures, death, and hospitali-zation and poses a serious threat to the health of the elderly. The construction of animal models constitutes the basis for research in its pathogenesis, clinical intervention and treatment planning. Due to the complexity of the sarcopenia phenotype, it is crucial to select an optimal modeling method and construct a suitable animal model. In this article,we reviewed the progress in methodology in animal model construction for sarcopenia in recent years, providing reference for the research in the pathogenesis, prevention, and treatment of sarcopenia.