老年高血压患者动态血压特点及其影响因素
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(山西医科大学第三医院·山西白求恩医院·山西医学科学院·同济山西医院心血管内科,太原 030032)

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R544.1

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Characteristic and influencing factors of ambulatory blood pressure in elderly patients with hypertension
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(Department of Cardiology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China)

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    摘要:

    目的 观察老年高血压患者动态血压的特点,探讨老年高血压患者血压昼夜节律的影响因素。方法 回顾性分析2021年1月至6月山西白求恩医院高血压门诊收治的符合条件的296例老年高血压患者(年龄≥60岁)的临床资料。根据血压昼夜节律将患者分为杓型组(56例)、非杓型组(134例)和反杓型组(106例)。收集患者一般资料,完善24h动态血压监测、动脉硬化监测、24h尿电解质及24h尿微量白蛋白检测。采用SPSS 26.0统计软件进行数据分析。根据数据类型,分别采用单因素方差分析、Kruskal-Wallis H检验或χ2检验进行组间比较。采用二分类logistic回归分析血压昼夜节律的影响因素。结果 血压昼夜节律异常(非杓型组和反杓型血压组)患者比例明显高于血压节律正常(杓型组)患者比例(81.1%和18.9%);杓型组患者年龄低于非杓型组和反杓型组[68.00(65.00,70.00)和70.00(68.00,73.00),71.00(69.00,74.00)岁];杓型组吸烟比例明显低于非杓型组和反杓型组(7.1%和39.6%,47.2%),差异均有统计学意义(P<0.05)。杓型组、非杓型组和反杓型组夜间血压下降率依次递减[12.40%(10.70%,14.78%)、3.70%(1.58%,5.83%)和-4.50%(-8.00%,-2.30%)],差异有统计学意义(P<0.05)。反杓型组右肱-踝脉搏波传导速度(baPWV)高于非杓型组、杓型组[(1851.57±215.87)和(1747.81±244.65),(1687.00±201.61)cm/s];反杓型组左baPWV高于非杓型组、杓型组[(1869.13±232.15)和(1758.57±259.18),(1692.25±205.34)cm/s],差异均有统计学意义(P<0.05)。反杓型组24h尿钠低于杓型组[83.00(59.00,114.75)和102.50(84.00,126.75)mmol/24h];24h尿微量白蛋白高于杓型组[48.25(36.33,61.64)和41.09(32.00,48.94)mg/24h],差异均有统计学意义(P<0.05)。二分类logistic回归分析结果显示,年龄(OR=1.328,95%CI 1.178~1.496;P<0.001)和吸烟史(OR=14.953,95%CI 4.706~47.511;P<0.001)是老年高血压患者血压昼夜节律的独立危险因素;24h尿钠(OR=0.988,95%CI 0.979~0.998;P=0.021)是老年高血压患者血压昼夜节律的独立保护因素。结论 老年高血压患者血压昼夜节律异常发生率明显增高;年龄、吸烟史是老年高血压患者血压昼夜节律的独立危险因素,24h尿钠是老年高血压患者血压昼夜节律的独立保护因素。

    Abstract:

    Objective To observe the characteristics of ambulatory blood pressure in elderly patients with hypertension and explore the factors affecting the circadian rhythm of blood pressure in them. Methods A retrospective study was conducted of the clinical data of a total of 296 eligible elderly hypertensive patients (aged ≥60 years) treated at the Hypertension Clinic of Shanxi Bethune Hospital from January to June of 2021. According to the circadian rhythm of blood pressure, they were divided into a dipper group (n=56), a non-dipper group(n=134), and a reverse dipper group (n=106). The data collected included the general clinical information of the patients, 24 h ambulatory blood pressure monitoring, arteriosclerosis monitoring, 24 h urine electrolytes, and 24 h urine microalbumin detection. SPSS statistics 26.0 was used for data analysis. According to the data type, one-way ANOVA, Kruskal-Wallis H test orχ2 test was used to compare the groups. Binary logistic regression was performed to analyze the factors influencing the circadian rhythm of blood pressure. Results Abnormal circadian rhythm of blood pressure (non-dipper group and reverse dipper group) was found in 81.1% of the elderly hypertensive patients, which was significantly higher than that of the normal blood pressure rhythm group (dipper group). The age of the dipper group was lower than that of the non-dipper group and the reverse dipper group [68.00 (65.00,70.00) vs 70.00 (68.00,73.00), 71.00 (69.00,74.00) years], and the differences were statistically significant (P<0.05). The proportion of smokers in the dipper group was lower than that in non-dipper group and reverse dipper group(7.1% vs 39.6%, 47.2%), and the differences were statistically significant (P<0.05). The nocturnal blood pressure drop rate in the dipper group, non-dipper group and reverse dipper group decreased gradually [12.40% (10.70%,14.78%),3.70% (1.58%,5.83%),-4.50% (-8.00%, -2.30%)], and there were significant differences among all groups (P<0.05). The right brachial-ankle pulse wave velocity (baPWV) in the reverse dipper group was significantly higher than that in the non-dipper group and the dipper group[(1 851.57±215.87) vs (1 747.81±244.65), (1 687.00±201.61)cm/s]; the left baPWV in the reverse dipper group was higher than that in the non-dipper group and the dipper group [(1 869.13±232.15) vs (1 758.57±259.18), (1 692.25±205.34) cm/s]; the differences were statistically significant (P<0.05). The 24 h urinary sodium in the reverse dipper group was lower than that in the dipper group[83.00 (59.00,114.75) vs 102.50 (84.00,126.75) mmol/24h]; the 24 h urine microalbumin in the reverse dipper group was higher than that in the dipper group[48.25(36.33,61.64) vs 41.09(32.00,48.94) mg/24h]; the difference was statistically significant (P<0.05). Binary logistic regression analysis showed that age (OR=1.328,95%CI 1.178-1.496; P<0.001) and smoking history (OR=14.953,95%CI 4.706-47.511; P<0.001) were independent risk factors, and 24 h urinary sodium (OR=0.988,95%CI 0.979-0.998; P=0.021) was an independent protective factor of the circadian rhythm of blood pressure in elderly hypertensive patients. Conclusion The incidence of abnormal circadian rhythm of blood pressure significantly increase in the elderly hypertensive patients. Age and smoking history are independent risk factors, and 24 h urine sodium was an independent protective factor of the circadian rhythm of blood pressure in elderly hypertensive patients.

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王建国,任洁.老年高血压患者动态血压特点及其影响因素[J].中华老年多器官疾病杂志,2024,23(1):43~47

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  • 收稿日期:2023-03-29
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  • 在线发布日期: 2024-01-28
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