Intrinsic capacity refers to the combination of one′s physical and mental abilities, and its framework comprises mobility, vitality, cognition, psychological, and sensory domains. Intrinsic capacity plays an important role in healthy aging. Studies on the mechanism of intrinsic capacity show that chronic low-grade inflammation accompanying aging process may play an important role in its decline by acting on all the domains. In this article, we reviewed the relationship between chronic low-grade inflammation and intrinsic capacity.