Objective To study the quality of life and its influencing factors in the elderly patients with pruritus.Methods A total of 140 elderly patients with pruritus admitted to the General Hospital of Medical Community of Chengmai People′ s Hospital from June 2021 to June 2022 were enrolled as the study subjects. The patients were evaluated using dermatology life quality index (DLQI), and the factors affecting their quality of life were analyzed by binary logistic regression model. SPSS 19.0 was used for data analysis. inter group comparison was perfomed using χ² test. Results The mean DLQI score in the elderly patients with pruritus was the highest at (1.51±0.36) points for symptom perception, followed by (1.37±0.21) points for work and study. The total DLQI score was (10.27±2.38) points, and the disease had a mild impact on the life of 15.71% (22/140) patients, a moderate impact on the life of 62.86% (88/140) patients and a huge or very huge impact on the life of 14.29% (20/140) patients. Binary logistic regression analysis indicated that the course of pruritus (OR=2.201, 95%CI 1.743-2.779), duration of single pruritus (OR=1.756, 95%CI 1.161-2.655), accompanying symptoms (OR=3.404, 95%CI 1.152-10.063), pruritus site (OR=4.716, 95%CI 1.881-11.825), lesion area (OR=1.744, 95%CI 1.144-2.658), pruritus degree (OR=2.199, 95%CI 1.610-3.003), anxiety (OR=2.349, 95%CI 1.250-4.415) and sleep disorders (OR=1.952, 95%CI 1.182-3.224) were independent factors affecting the patients′ quality of life(P＜0.05). Conclusion Pruritus in the elderly can have adverse effects on the quality of life of patients to varying degrees, and the long course of illness, severe pruritus, private pruritus, and comorbid anxiety and sleep disorders are independent factors affecting the patients′ quality of life. It is suggested that, in addition to active measures to relieve pruritus symptoms, attention is necessary to adverse emotions and sleep disorders.