Abstract:As a common geriatric syndrome, frailty is characterized by multiple system dysfunction. Heart failure(HF) is a group of syndromes caused by various structural or functional diseases of the heart, leading to impaired ventricular filling and/or blood ejection capacity,which often complicate with frailty and relate to decreased physical function, falls, disability, and cognitive decline.Frailty is common in older patients with heart failure, and both frailty and heart failure share common mechanistic features, including strong relations with a high burden of comorbidities, inflammation, and sarcopenia. Frailty is associated with worse clinical symptoms, organ function, and life quality in older patients with heart failure, so it is critical to develop simple, easy-to-use, and well-validated assessment tools to identify frailty. These assessment tools can efficiently and quickly identify frail patients with HF in routine clinical settings to better inform prognosis.In older patients with heart failure and frailty, novel management strategies, such as those addressing multiple domains through multidisciplinary assessment and intervention, should be investigated further. Raising awareness of the shared mechanism of HF with frailty and managing frailty may help improve quality of life and have a substantial impact on prognosis in HF patients.