朱亚玲,刘春莹,谭颖颖.肠道微生物群对糖尿病肾病患者胰岛素分泌及炎症通路影响的研究进展[J].中华老年多器官疾病杂志,2023,22(4):299~302 |
肠道微生物群对糖尿病肾病患者胰岛素分泌及炎症通路影响的研究进展 |
Research progress in influence of gut microbiota on insulin secretion and inflammatory pathways in patients with diabetic nephropathy |
投稿时间:2022-05-30 |
DOI:10.11915/j.issn.1671-5403.2023.04.062 |
中文关键词: 糖尿病肾病 肠道微生物群 短链脂肪酸 胆汁酸 内毒素 |
英文关键词:diabetic nephropathy intestinal microecology short-chain fatty acids bile acids endotoxins This work was supported by the National Natural Science Foundation of China |
基金项目:国家自然科学基金(81873296);陕西省第三届名中医(中药师)传承工作室建设项目(2019002) |
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中文摘要: |
目前,糖尿病肾病(DN)已成为我国主要的公共卫生问题之一,多数患者最终走向终末期肾病。近年来,在“肠-肾轴”的研究背景下,越来越多证据支持肠道微生物与肾脏的双重影响。本文将具体阐述肠道微生物群及其代谢产物(短链脂肪酸轴、胆汁酸轴、内毒素轴)在DN不同时期对胰岛素分泌及炎症反应的影响,总结肠道微生物群在DN早期、中晚期的不同作用路径,为DN多靶点治疗提供新的研究思路。 |
英文摘要: |
Diabetic nephropathy (DN) has been one of the major public health problems in China, and most patients eventually develop end-stage renal disease. In the context of research in "gut-kidney axis" in recent years, increasing evidence supports the dual influence of gut microbiota and kidney. This article elaborates the effects of gut microbiota of its metabolites (short-chain fatty acids axis, bile acids axis, and endotoxin axis) on insulin secretion and inflammatory response in different DN stages, and summarizes the different pathways of gut microbiota in early and middle/late DN stages in a view to providing new research orientations for multi-target therapy of DN. |
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