| 沈璞,韩振国,张玉龙,霍宇琪.免疫评分系统在结直肠癌中应用的研究进展[J].中华老年多器官疾病杂志,2023,22(1):76~80 |
| 免疫评分系统在结直肠癌中应用的研究进展 |
| Research progress of application of immunoscore system in colorectal cancer |
| 投稿时间：2022-01-17 |
| DOI：10.11915/j.issn.1671-5403.2023.01.015 |
| 中文关键词: 结直肠癌 免疫评分 预后指标 |
| 英文关键词:colorectal cancer immunoscore prognostic indicator This workwas supported by the 136 Revitalization Medical Project of Shanxi Province |
| 基金项目:山西省136兴医工程项目(2021YZ07,2021YZ08) |
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| 中文摘要: |
| 结直肠癌是常见的消化系统恶性肿瘤,发病率和死亡率呈逐年上升趋势。TNM分期系统是目前国际上最为通用的肿瘤分期系统,但其分期标准仅基于肿瘤细胞本身特征,未能纳入患者整体免疫情况,在对患者预后的指导中逐渐显露不足。因此,在量化分析肿瘤微环境中免疫细胞的基础上,提出了免疫评分系统。近年多项研究证实,免疫评分系统能够更精准地评估结直肠癌患者的临床预后,且效果优于TNM分期。此外,免疫评分系统在辅助放化疗、评估免疫治疗疗效等方面也发挥重要作用,可进一步优化TNM分期系统及风险分层,有利于制定肿瘤患者的个体化治疗方案。本文就免疫评分系统在结直肠癌患者预后及疗效评估方面的研究进展进行综述。 |
| 英文摘要: |
| Colorectal cancer is a common malignant tumor of digestive system, and its incidence rate and mortality are increasing year by year. TNM staging system is the most commonly used tumor staging system in the world at present, but its staging standard is only based on the characteristics of tumor cells themselves, which cannot be included in the overall immune situation of patients, and the system has gradually showed insufficient guidance for the prognosis of patients. Therefore, based on the quantitative analysis of immune cells in tumor microenvironment, an immunoscore system was proposed. In recent years, many studies have confirmed that the immunoscore system can more accurately evaluate the clinical prognosis of colorectal cancer patients, and shows better effect than TNM staging. In addition, the immunoscore system also plays an important role in adjuvant radiotherapy and chemotherapy and in evaluation of efficacy of immunotherapy, etc. It can further optimize the TNM staging system and risk stratification, which is conducive to the development of individualized treatment plans for cancer patients. This article reviews the research progress of immunoscore system in the prognosis and efficacy evaluation of colorectal cancer patients. |
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