基于任务切换范式的认知功能评估工具研究
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(1.北京师范大学 认知神经科学与学习国家重点实验室,北京 100875;2.北京师范大学 老年脑健康研究中心,北京 100875;3.中国中医科学院中医临床基础医学研究所,北京 100700)

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R749.16;B842.1

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国家自然科学基金面上项目(32171085);国家自然科学基金(91109000);科技创新2030项目(2022ZD0211600);国家重点研发计划项目(20187FC1315200);中央级公益性科研院所基本科研业务费专项资金(Z0739)


Validation of a cognitive assessment tool based on task switching paradigm
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(1. State Key Laboratory of Cognitive Neuroscience and Learning,Beijing 100875, China;2. Beijing Aging Brain Rejuvenation Initiative Center, Beijing Normal University, Beijing 100875, China;3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China)

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    摘要:

    目的 检验一款基于任务切换范式的认知功能评估工具在表征认知水平方面的有效性。方法 选择北京师范大学老年脑健康中心2019年7月至2020年1月招募的60名社区中老年人为研究对象,并按人口学信息分组。使用自编认知功能评估工具和成套神经心理测验评估受试者在一般认知功能、执行功能等认知领域的表现。采用SPSS 24.0统计软件进行数据分析。根据数据类型分别采用独立样本t检验或单因素方差分析进行组间比较,Dunnett′s t用于事后多重比较。采用Pearson相关分析自编认知功能评估工具与神经心理测验结果的相关性。通过配对样本t检验对自编认知功能评估工具和成套神经心理测验的结果指标进行一致性分析,并绘制得分柱状图和分数累积分布图展示结果的分布情况。结果 Pearson相关分析显示,中老年人在自编认知功能评估工具中的得分、反应时等指标与神经心理测验中一般认知能力测验(MMSE)和执行功能测验[连线测验B部分(TMT-B)、颜色词测验(SCWT)]的结果显著相关(|r|:0.272~0.448,均P<0.05)。配对样本t检验结果显示自编认知功能评估工具和神经心理测验的结果无显著差异(MMSE:t=-0.726,P=0.471;TMT-B:t=-0.530,P=0.598;SCWT时间:t=-0.366,P=0.716;SCWT数目:t=-0.544,P=0.588)。独立样本t检验和单因素方差分析结果显示,自编认知功能评估工具的评估结果不受教育程度和性别差异的影响(均P>0.05)。结论 本研究所使用的基于任务切换范式的认知功能评估工具可有效反映受试者的认知水平,是一款具有普适性的快速认知障碍风险筛查工具。

    Abstract:

    Objective To detect the validity of a task switching paradigm-based cognitive assessment tool. Methods From July 2019 to January 2020,60 middle-aged and elderly people in the community were recruited from the Beijing Aging Brain Rejuvenation Initiative Center of Beijing Normal University, and then they were grouped by demographic information. Our self-designed cognitive tool and other neuropsychological tests [such as mini-mental state examination (MMSE), Rey auditory verbal learning test, trail-making test B (TMT-B), stroop color word test (SCWT) and so on] were used to assess the performances of the subjects in general cognitive function, executive function and other areas of cognition. SPSS statistics 24.0 was used for data analysis. According to the data type, independent sample t test or one-way ANOVA were used for intergroup comparison in demographic variables, and Dunnett′s test for multiple comparisons was conducted for post hoc comparison. Pearson correlation analysis was employed to analyze the correlation in the results from our cognitive test and from above mentioned neuropsychological tests. The consistency of the results of our cognitive test and neuropsychological tests was analyzed by paired samples t test, and the score histogram and cumulative score distribution chart were drawn to show the distribution of the results. Results Pearson correlation analysis indicated that the total score and average reaction time from our cognitive test were significantly correlated with the results of the neuropsychological tests in general cognitive function (MMSE) and executive function (TMT-B and SCWT) (|r |:0.272-0.448, all P<0.05). Furthermore, the results of paired sample t test showed that there were no significant differences between the results of the two evaluation methods (MMSE:t=-0.726, P=0.471; TMT-B:t=-0.530, P=0.598; SCWT time:t=-0.366, P=0.716; SCWT number:t=-0.544, P=0.588). Finally, the independent sample t-test and one-way ANOVA suggested that the results of our cognitive test were not affected by educational levels and genders of the elderly (all P>0.05). Conclusion Our self-designed task switching paradigm-based cognitive tool can well reflect the cognitive level of the subjects, and is suitable as a wildly-used rapid cognitive screening tool.

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姜岚莉,戴向唯,李鹤,张占军.基于任务切换范式的认知功能评估工具研究[J].中华老年多器官疾病杂志,2022,21(12):892~898

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  • 收稿日期:2022-07-27
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  • 在线发布日期: 2023-01-09
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