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解放军总医院医学创新研究部、国家老年疾病临床医学研究中心(解放军总医院)、解放军总医院第六医学中心心血管病医学部
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
郭嘉羽,于康,董祈,张玉.肺癌住院患者衰弱患病率及其影响因素[J].中华老年多器官疾病杂志,2022,21(10):755~759
肺癌住院患者衰弱患病率及其影响因素
Prevalence of frailty in inpatients with lung cancer and analysis its influencing factors
投稿时间:2022-06-08  
DOI:10.11915/j.issn.1671-5403.2022.10.163
中文关键词:  肺癌  住院患者  衰弱  营养风险  肌肉量
英文关键词:lung cancer  inpatients  frailty  nutritional risk  muscle mass This work was supported by National Nutrition Research Fund
基金项目:全民营养研究基金(CNSNNSRG2021-129)
作者单位E-mail
郭嘉羽 中国医学科学院北京协和医学院北京协和医院临床营养科,北京 100730 yuk1997@sina.comprevalence 
于康 中国医学科学院北京协和医学院北京协和医院临床营养科,北京 100730 yuk1997@sina.comprevalence 
董祈 中国医学科学院北京协和医学院北京协和医院临床营养科,北京 100730 yuk1997@sina.comprevalence 
张玉 中国医学科学院北京协和医学院北京协和医院临床营养科,北京 100730 yuk1997@sina.comprevalence 
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中文摘要:
      目的 调查肺癌住院患者衰弱患病率,并进一步分析其相关影响因素。方法 连续定点纳入2021年12月至2022年4月北京协和医院符合纳入及排除标准的肺癌住院患者,收集其一般人口学资料、病史资料、营养相关资料及实验室检查资料。采用Fried衰弱表型评估衰弱状况,采用营养风险筛查2002进行营养风险筛查,采用多频生物电阻抗法测定人体成分。采用Stata/SE 16.0软件进行数据分析。根据数据类型,组间比较分别采用χ2检验及方差分析。结果 共纳入肺癌患者109例,其中衰弱39例(35.8%),衰弱前期45例(41.3%),非衰弱25例(22.9%)。病理类型为小细胞肺癌、患有共病、有营养风险的患者其衰弱患病率显著升高,差异均有统计学意义(χ2=6.38,14.25,12.02;均P<0.05)。多因素logistic回归分析显示,共病数、肌肉量、美国东部肿瘤协作组体力状况评分和血清白蛋白含量是衰弱和衰弱前期的独立影响因素(β=0.653、-0.980,1.169,-0.128;均P<0.05)。结论 肺癌住院患者普遍处于衰弱或衰弱前期。患者的共病情况、营养状况、肌肉量及活动能力与衰弱状况有密切关联。
英文摘要:
      Objective To investigate the prevalence of frailty in inpatients with lung cancer and analyze its influencing factors. Methods From December 2021 to April 2022, inpatients with lung cancer in Peking Union Medical College Hospital who met the inclusion and exclusion criteria were consecutively enrolled. Their data concerning demography, medical history, nutrition and laboratory tests were collected. Fried frailty phenotype was used to assess frailty status, Nutritional Risk Screening 2002 to screen nutritional risks, and multi-frequency bioelectric impedance analysis to determine body composition. Stata/SE 16.0 was used for data analysis. Depending on data type, comparison between groups was performed using χ2test or analysis of variance.Results A total of 109 lung cancer inpatients were included, among whom 39 cases (35.8%) were of frailty, 45 cases (41.3%) of pre-frailty, and 25 cases (22.9%) of non-frailty. The prevalence of frailty was significantly higher in patients with small cell lung cancer, comorbidities and nutritional risks (χ2=6.38,14.25,12.02; all P<0.05). Multivariate logistic regression analysis showed that the number of comorbidities, muscle mass, Eastern Cooperative Oncology Group performance status, and serum albumin were independent influencing factors of frailty and pre-frailty(β=0.653, -0.980,1.169, -0.128;all P<0.05). Conclusion Frailty or pre-frailty is common in inpatients with lung cancer. The comorbidities, nutritional status, muscle mass and physical function are strongly associated with frailty status.
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