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解放军总医院医学创新研究部、国家老年疾病临床医学研究中心(解放军总医院)、解放军总医院第六医学中心心血管病医学部
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
赵欢,杨伟,王洁妤,罗鸿宇,马艺欣,佀思聪,诸国华.老年糖尿病患者β2微球蛋白的影响因素及其与认知功能的相关性[J].中华老年多器官疾病杂志,2022,21(8):587~591
老年糖尿病患者β2微球蛋白的影响因素及其与认知功能的相关性
Influencing factors of β2 microglobulin and its correlation with cognitive function in elderly patients with diabetes mellitus
投稿时间:2022-02-11  
DOI:10.11915/j.issn.1671-5403.2022.08.126
中文关键词:  老年人;糖尿病;β2微球蛋白;认知功能
英文关键词:aged; diabetes mellitus; β2-microglobulin; cognitive function This work was supported by the Principal Nurturing Fund of Capital Medical University
基金项目:首都医科大学校长培育基金(PYZ201844);北京市医院管理中心培育项目(PX2022032)
作者单位E-mail
赵欢 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
杨伟 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
王洁妤 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
罗鸿宇 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
马艺欣 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
佀思聪 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
诸国华 首都医科大学宣武医院老年医学科,北京 100053 weiyang79@xwh.ccmu.edu.cninfluencing 
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中文摘要:
      目的 探讨老年糖尿病患者β2微球蛋白(β2M)的影响因素及其与认知功能的相关性。方法 选取2018年5月至2019年5月于宣武医院内分泌科与老年医学科住院诊治的300例老年糖尿病患者为研究对象,收集患者基础临床资料、炎症和生化指标,应用蒙特利尔认知评估量表(MoCA)评估认知功能。根据β2M水平将患者分为高β2M组(n=149)和低β2M组(n=151)。采用SPSS 22.0统计软件进行数据分析。根据数据类型,分别采用t检验、Mann-Whitney U检验或χ2检验进行组间比较。应用Pearson相关性分析和多元线性回归分析β2M与临床指标的相关性。应用logistic回归分析认知功能障碍(CI)的影响因素。结果 与高β2M组相比,低β2M组患者年龄、糖尿病病程、白介素6(IL-6)、同型半胱氨酸(HCY)、甘油三酯(TG)、肌酐、尿素氮(BUN)、尿酸水平更低,差异有统计学意义(P<0.05)。多元逐步线性回归方程显示,肌酐、BUN、IL-6、尿酸与β2M呈正相关(P<0.05)。单因素logistic回归分析结果显示,年龄、β2M、合并脑卒中、肌酐、BUN是老年糖尿病患者合并认知障碍的危险因素(P<0.05),多因素logistic回归分析结果显示,年龄、β2M和脑卒中为老年糖尿病患者认知障碍的独立危险因素(P<0.05)。结论 老年糖尿病患者β2M水平不仅与肾功能下降相关,还是认知障碍的独立危险因素。
英文摘要:
      Objective To explore the influencing factors of β2 microglobulin (β2M) and its correlation with cognitive function in the elderly patients with diabetes mellitus. Methods A total of 300 elderly diabetic patients hospitalized in the departments of endocrinology and geriatrics of Xuanwu Hospital from May 2018 to May 2019 were recruited in this study. General clinical data, inflammatory indicators, and results of biochemical tests were collected. The cognitive function was evaluated using Montreal cognitive assessment (MoCA). The patients were divided into high and low β2M groups (149 and 151 patients respectively) according to β2M level. Statistical analyses were performed using SPSS statistics 22.0. Data comparison between two groups was performed using t test, Mann-Whitney U test or Chi-square test depending on data types. The correlation of β2M level with clinical indicators was analyzed by Pearson correlation analysis and multiple liner regression analysis. Logistic regression analysis was employed to analyze the affecting factors of cognitive impairment (CI) in the elderly diabetic patients. Results Compared with the high β2M group, the low β2M group had younger age, shorter diabetic duration, and lower levels of interleukin 6 (IL-6), homocysteine (HCY), triglyceride (TG), creatine, blood urea nitrogen (BUN) and uric acid (P<0.05). Multiple linear stepwise regression equation showed that β2M had positive correlations with creatine, BUN, IL-6 and uric acid (P<0.05). Univariate logistic regression analysis indicated that age, β2M, stroke, creatine and BUN were risk factors for CI in elderly patients with diabetes mellitus(P<0.05). Multivariate logistic regression analysis suggested that age, β2M and stroke were independent risk factors of CI in the elderly patients with diabetes mellitus (P<0.05). Conclusion β2M in elderly patients with diabetes mellitus is not only associated with declining renal function, but also an independent risk factor of CI.
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