Diabetes mellitus and coronary heart disease are common chronic diseases in clinical practice. With the aggravation of aging in China, the incidence rates of diabetes mellitus and coronary heart disease are increasing year by year. Evidence shows that diabetes mellitus and coronary heart disease have a certain correlation in their occurrence and development. In this article, we reviewed the pathogenesis, treatment strategies and precise diagnosis and treatment under the guidance of bioinformatics of diabetes complicated with coronary heart disease, hoping to provide a theoretical basis for the clinical treatment of such diseases.