Macrophages, one of the most abundant white blood cells, play an important immune role in tissue damage and repair. Myocardial fibrosis is pathophysiological process of hypertension, diabetic cardiomyopathy, myocardial infarction and other common diseases. In the process of myocardial fibrosis, macrophage can alter the expression of collagen protein through a variety of ways, such as adjusting the synthesis and secretion of cytokines and growth factors, affecting their phagocytosis and polarization caused by the occurrence of myocardial fibrosis. Targeting macrophages may be a new therapeutic approach to preventing and improving myocardial fibrosis