Atherosclerotic diseases and cancer pose a serious threat to human health. Clinical studies have shown that atherosclerotic diseases are significantly correlated with the pathogenesis of cancer. Patients with atherosclerosis have a higher probability of developing cancer than those without, and the cancer population has a remarkably higher probability of developing atherosclerotic diseases when compared with the non-cancer population. Atherosclerotic diseases and cancer seem to be two independent diseases, but there are certain association in their pathogenesis. The two not only have common risk factors, but also have related molecular mechanisms. Because of the importance of the two diseases to human health, the correlations between them and their mechanisms have attracted increasing attention.