Post-thrombolic syndrome (PTS) in lower extremity deep vein is a group of diseases secondary to lower extremity deep vein thrombosis (DVT). Although the pathogenesis of PTS remains unclear, its high incidence and harm seriously affect the patients′ life quality. This article reviews its risk factors such as gender, age, obesity, genetic factors, treatment protocol for acute DVT, choice of anticoagulants, DVT recurrence, varicose veins, wearing stretch hoses, and functional exercises of the lower extremity, exploring possible solutions and interventions to reduce the incidence of PTS.