Objective To retrospectively analyze the related factors of hospitalized death in patients with bronchiectasis complicated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 111 patients with bronchiectasis complicated with AECOPD admitted in our hospital from January 2015 to June 2020 were enrolled in this study. According to their prognostic outcomes, they were divided into survival group and death group. The general information, clinical manifestations, lung function, results of laboratory examinations and length of hospital stay were collected and analyzed to screen the related factors affecting the in-hospital mortality in the two groups. SPSS statistics 24.0 was used for the data analysis. According to the data types, Chi-square test, student′s t test or Mann-Whitney rank sum test were employed for intergroup comparison. Logistic regression analysis was adopted to analyze the risk factors of death. Results A total of 31 risk factors were screened out for analysis. Univariate analysis showed that there were significant differences in age, underlying comorbidities, body mass index (BMI), granulocyte/lymphocyte ratio (NLR), serum albumin (ALB), pseudomonas aeruginosa infection, forced expiratory volume in one second as percentage of predicted volume(FEV₁%pred), blood gas analysis(BGA), partial pressure of carbon dioxide(PCO₂), oxygenation index (OI), Bhalla score of chest imaging and annual symptom duration between the two groups (P<0.05). Multivariate logistic regression analysis indicated that NLR, FEV₁%pred and Bhalla score were risk factors for death in patients with bronchiectasis complicated with AECOPD. Conclusion Increased NLR, decline of FEV₁%pred and low Bhalla score of chest imaging are independent risk factors for death in patients with bronchiectasis complicated with AECOPD.