Abstract:Mitochondrial dysfunction caused by mitochondrial deoxyribonucleic acid mutation, excess reactive oxygen species (ROS) production, decreased biogenesis, dynamics dysregulation, and mitophagy disorder might be the main factor leading to the occurrence and development of sarcopenia. Nowadays, physical exercise, because of its enhancing or restoring mitochondrial function, has been well accepted as an essential regime in the prevention and treatment of the disease. ROS-targeted therapies, including vitamin E/C, resveratrol, and targeted antioxidants, can regulate mitochondria to improve muscle quantity and function. Improving mitochondrial function can be a target for sarcopenia treatment.