Objective To investigate the predictive value of myocardial performance (Tei) index for prognosis in patients with sepsis-induced myocardial injury. Methods The clinical data of 75 patients with sepsis-induced myocardial injury treated in intensive care unit of Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine from June 2019 to March 2020 were collected and retrospectively analyzed. The 28-day prognosis was taken as the observational end event, and the patients were divided into survival group and death group. Statistical analyses were performed using SPSS statistics 19.0. Student′s t test was used to compare the differences of first bedside Tei index and serum level of venous cardiac troponin I (cTn-I) between the 2 groups, and receiver operating characteristic (ROC) curve analysis was applied to detect the accuracy of Tei index in the prediction of prognosis. Results The death group had significantly higher Tei index and cTn-I level than the survival group (P<0.05). The area under ROC curve (AUC) of Tei index was 0.802; the cut-off value was 0.55; the sensitivity was 64.34% and the specificity was 88.52%. Meanwhile AUC of cTn-I was 0.756; the cut-off value was 0.76 ng/ml; the sensitivity was 57.12% and the specificity was 85.23%. There was no statistical difference between Tei index and cTn-I in the prediction (Z=0.835, P>0.05). Conclusion Tei index and cTn-I level are associated with mortality in the patients with sepsis-induced myocardial injury. Tei index is helpful for the prediction of prognosis for these patients.