Objective To explore the risk factors of coronary heart disease (CHD) in patients with chronic obstructive pulmonary disease (COPD) . Methods A total of 120 patients who were admitted into Affiliated Hospital of Xuzhou Medical University due to acute exacerbation of COPD from January 2019 to January 2020 were enrolled in the study. According to being accompanied with CHD or not, they were divided into COPD group and COPD+CHD group. The demographic data, and related parameters of clinical and laboratory tests were collected and compared between the two groups. SPSS statistics 22.0 was used for data analysis. According to different data type, t test, Mann-Whitney U test or χ² test was used for data comparison between two groups. Logistic regression was used to analyze the influencing factors of COPD combined with CHD. Results The COPD+CHD group had significantly higher ratios of hyperglycemia and hypertension, larger smoking amount, and higher leukocyte count, neutrophil proportion and fibrinogen when compared with the COPD group (P<0.05). What′s more, the ratio of forced expiratory volume in the first second (FEV1) to forced vital capacity (FEV1/FVC), percentage of FEV1 of the predicted value (FEV1%pred), and arterial partial pressure of oxygen (PaO₂) were obviously lower in the COPD+CHD group than the COPD group (P<0.05). Multivariate logistic regression analysis showed that smoking, declined pulmonary function, hypertension, hyperglycemia and decreased PaO₂ were independent risk factors for CHD in COPD patients (P<0.05). Conclusion Smoking, hypertension, hyperglycemia, declined lung function and poor oxygenation can increase the risk of CHD in COPD patients. Special attention should be paid to the patients with relevant characteristics in clinical practice.