Cardiovascular disease remains one of the major public health problems worldwide with high morbidity and mortality, and myocardial infarction remains the leading cause of death. The rapid development of microarray technology and high-throughput sequenc-ing technology helps to gradually reveal the role of long non-coding RNA (lncRNA) in the occurrence and development of cardiovascular disease. LncRNA regulates gene expression at transcriptional and post-transcriptional levels through epigenetic action. A large number of studies have shown that lncRNA plays an important role in the regulation of atherosclerosis, acute myocardial infarction, and other cardiovascular diseases. This article reviews the biological mode of lncRNA and research progress in its role in the pathogenesis, diagnosis and treatment of coronary heart disease.