Aging problem is becoming more and more serious, which has brought new challenges to the diagnosis and treatment of diseases for the elderly. Comprehensive geriatric assessment is the core technology in geriatric researches, and it is to make a comprehensive individualized evaluation of physical functions, mental psychology, social environment, quality of life, polypharmacy and other aspects in the elderly patients. However, polypharmacy is one of the common conditions for the aged, and it increases the risk of adverse drug reactions. Therefore, effective evaluation and intervention of polypharmacy for the elderly has become an urgent issue. In this review, we evaluate the current status of polypharmacy in the elderly and the research progress on evaluation tools for prescriptions in elderly individuals.