Abstract:Objective To explore the characteristics and influencing factors in patients with Parkinson′s disease (PD) complicated with nocturnal hypertension (NH). Methods From January 2017 to January 2020, a total of 150 PD patients admitted to Beijing Tiantan Hospital were consecutively recruited. The patients received 24-hour ambulatory blood pressure (BP) monitoring and were divided into PD with NH (PD-NH) group and PD with no NH (PD-nNH) group. The patient′s demographic data was recorded, and the scales for outcomes in Parkinson′s disease-autonomic (SCOPA-AUT) was used to evaluate the patient′s autonomic symptoms. The standard deviations of systolic BP and diastolic BP in the daytime, at night and during the whole day were collected. Echocardiography was performed, and data were recorded of the left atrium diameter, the left ventricular end-diastolic diameter, the left ventricular posterior wall thickness, end-diastolic interventricular septal thickness and left ventricular ejection fraction. SPSS statistics 21.0 was used for data analysis. Results Among 150 PD patients, 96 were complicated with NH. Compared with the PD-nNH group, more patients had hypertension and higher SCOPA-AUT score in the PD-NH group (P<0.05). The standard deviations of all-day systolic BP, night-time systolic BP and night-time diastolic BP in the PD-NH group were significantly higher than those in the PD-nNH group (P<0.05). The end-diastolic interventricular septal thickness and the left ventricular posterior wall thickness in PD-NH group were significantly greater than those in PD-nNH group (P<0.05). Logistic regression analysis showed that the standard deviation of night-time systolic BP (OR=1.160,95%CI 1.010-1.332, P=0.035) and the end-diastolic interventricular septal thickness (OR=1.589,95%CI 1.059-2.384, P=0.025) were independent influencing factors of PD-NH. Conclusion The incidence of NH is high in PD patients. The increased standard deviation of systolic BP at night and the increase of end-diastolic interventricular septal thickness are independent influencing factors of PD-NH.