Objective To explore the difference of the therapeutic effects among different treatment methods for hyperlipidemia. Methods A total of 183 hyperlipidemia patients treated in the Hospital of Troop 75600 from January 2016 to January 2018 were enrolled as the research subjects, and were randomly divided into drug group, non-drug group and combined group, with 61 cases in each group. The patients from the drug group received atorvastatin treatment, those of the non-drug group received non-pharmaceutical interventions, such as health education, dietary adjustment and lifestyle optimization, and those of the combined group received both drug and non-drug interventions. After 12 weeks′ intervention, the treatment efficiency and blood levels of triglyceride (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) before and after the intervention were observed and evaluated for the improvement of symptoms and for therapeutic safety. SPSS statistics 16.0 was used to perform the statistical analysis. F-test or Chi-square test was employed for comparison between groups. Results The treatment efficiency was significantly higher in the combined group than in the drug group and the non-drug group (98.36% vs 81.97% and 73.77%, both P<0.05). And the combined group obtained obviously lower levels of TG [(1.41±0.35) vs (1.64±0.31) and (1.59±0.29)mmol/L], TC [(5.06±0.19) vs (5.96±0.68) and (6.11±0.51)mmol/L] and LDL-C [(2.56±0.43) vs (3.96±0.61) and (3.42±0.51)mmol/L], and decreased clinical symptom score [(3.16±0.51) vs (5.23±0.26) and (6.03±0.51)] when compared with the other 2 groups (P<0.05). The incidence of adverse reactions was significantly lower in the combined group than the drug group (4.92% vs 14.75%, P<0.05). Conclusion The combined intervention of drugs and non-drugs can significantly improve the clinical symptoms of hyperlipidemia patients, improve the efficiency of treatment, and have higher safety.