Objective To investigate the expression levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP) and cluster of differentiation 137 (CD137) in patients with acute myocardial infarction and their relationship with left ventricular remodeling (LVR). Methods A total of 124 hospitalized patients diagnosed with acute myocardial infarction were recruited from the Department of Cardiology of Yixing People′s Hospital from January 2017 to May 2018. Blood routine indicators, biochemical indicators, myocardial enzymes, serum troponin T (cTNT), NT-proBNP, hs-CRP and serum CD137 were routinely detected at admission, and echocardiography was performed during hospitalization and in 12 months after discharge. According to the results of echocardiography in 12 months′ follow-up, the patients were divided into LVR group (n=38) and non-LVR group (n=86). SPSS statistics 16.0 was used for data analysis. Pearson correlation analysis was applied for correlation analysis. Multivariate binary logistic regression analysis was used to analyze the independent risk factors of LVR, and receiver operating characteristic (ROC) curve was employed to evaluate the predictive value of NT-proBNP, hs-CRP and serum CD137 for LVR. Results NT-proBNP, hs-CRP and serum CD137 in the LVR group were significantly higher than those in non-LVR group at admission (P<0.05). Pearson correlation analysis showed that NT-proBNP (r=0.419), hs-CRP (r=0.209) and serum CD137 (r=0.604) were positively correlated with the increase of left ventricular end-diastolic diameter (all P<0.05). Binary logistic regressionanalysis showed that NT-proBNP, hs-CRP and serum CD137 levels were independent risk factors for LVR after acute myocardial infarction (P<0.05). The area under the ROC curve (AUC) of NT-proBNP, hs-CRP and serum CD137 levels in prediction of LVR occurrence was 0.753,0.722 and 0.690, respectively, and the AUC of the combined prediction of the 3 indicators was 0.805 (all P<0.05). Conclusion NT-proBNP, hs-CRP and serum CD137 levels are closely associated with LVR after acute myocardial infarction. The combined detection of them may be of certain predictive value for LVR.