Objective To investigate the psychological status of elderly patients during the epidemic period of coronavirus disease 2019(COVID-19) and its influencing factors. Methods Eighty-six elderly patients in the information management group established by our hospital were selected as the research subjects. The basic data of the patients were investigated by telephone, Wechat, QQ and other methods. The anxiety and depression of the patients were assessed by self-rating anxiety scale(SAS)and self-rating depression scale(SDS). SPSS statistics 18.0 was used to analyze the data. Multiple linear regression was used to analyze the related factors of depression and anxiety in elderly patients during the epidemic. Results During the epidemic period of COVID-19, the anxiety score of 86 patients with geriatric disease was 31.25-82.21(54.88±11.84), 20 patients with mild anxiety (23.53%), 53 patients with moderate anxiety (62.35%), and 12 patients with severe anxiety (14.12%). The depression score was 26.25-86.42(52.20±13.36), including 44 cases (64.71%) with mild depression, 18 cases (26.47%) with moderate depression, and 6 cases (8.82%) with severe depression. Multiple linear regression showed that the anxiety of the elderly patients was influenced by the concern about the epidemic, the great impact of COVID-19 on their lives, and the poor compliance with doctor′s orders for chronic diseases (all P<0.05). The place of residence, someone nearby is infected with COVID-19 are the influencing factors of depression in elderly patients (all P<0.05). Conclusion During the epidemic of COVID-19, the elderly patients obviously have anxiety and depression. Targeted intervention measures can be taken for the worries caused by the epidemic, the impact on their lives, and the compliance of their own chronic diseases with the doctor′s instructions to reduce mental disorders.