Abstract:Myocardial fibrosis (MF) refers to the reduction of normal myocardial cells in myocardium, proliferation of cardiac fibroblasts (CFs) increased proportion of collagen protein type Ⅰ and type Ⅲ, disordered arrangement, and excessive production and deposition of extracellular matrix (ECM). MF, the major pathological manifestation of cardiac remodeling, mainly causes the decrease of myocardial diastolic and systolic force. It is the end-stage manifestation of many cardiac conditions, such as hypertension, coronary heart disease, and arrhythmia. This paper reviews the research progress on the mechanism of MF to provide theoretical basis for finding effective targets and developing corresponding drugs.