Hydroxymethylglutaryl-coenzyme A reductase inhibitors (commonly known as statins) are among the most frequently used drug classes. Although primary and secondary prevention of cardiovascular diseases with statins can significantly reduce mortality and morbidity, adverse reactions occur in some patients taking statins, leading to concern about the negative consequences associated with their long-term use. It is therefore necessary to investigate the adverse reactions of statins with a view of seeking for effective management strategies, which will be conducive to the improved safety and increased patient compliance.