Rheumatoid arthritis (RA), one of common chronic autoimmune diseases, affects many systems. RA patients are at increased risk for cardiovascular diseases (CVD) when compared with general population. It is not only due to common CVD risk factors, such as obesity, hypertension, diabetes and smoking, but also associated with chronic inflammation caused by RA and usage of disease modifying anti-rheumatic drugs (DMARDs). Many studies showed that DMARDs can improve the remission rate of RA, but some may increase the risk of CVD, while others can have no effect or even decrease the CVD risk. This paper reviewed the impact of several RA drugs used commonly on risk of CVD so as to provide the reference for clinical practice.