Objective To investigate the clinical characteristics, prognosis and risk factors of amputation patients in recent 5 years in Macau Hospital Conde S. Januário. Methods The inpatient amputation patients in our hospital between January 2011 and December 2016 were enrolled in this study. The clinical data, including demography, amputation causes, risk factors, amputation level and concomitant diseases were recorded. SPSS statistics 21.0 was used to perform the statistical analysis. Multivariate logistic regression analysis was employed to determine the effects of risk factors on amputation level. Kaplan-Meier survival analysis was used to analyze the survival time after amputation.Results There were 175 consecutive patients (70.3±14.1 years old) with 208 amputation procedures recruited in this study. They were 71 cases of above knee amputation, 51 cases of below knee amputation, and 86 cases of foot or toe amputation. The causes of amputation were diabetic foot in 130 patients, diabetic foot and peripheral arterial disease in 41 patients, simple peripheral arterial disease in 19 patients, and other causes in 18 patients. Multivariate logistic regression analysis indicated that above knee amputation was associated with hypertension and peripheral artery disease(RR=2.012, P=0.215；RR=1.914, P=0.107), and foot or toe amputation was more prevalent in diabetes mellitus(RR=0.315, P=0.019). Kaplan-Meier survival analysis showed postoperative survival time was effected by amputation level, and survival time was shorter in those with above knee amputation. Conclusion The most common amputation cause in our hospital is diabetic foot, followed by vascular disease of lower extremity and other causes, such as trauma, tumor, and so on. Amputation level is associated with cardiovascular risk factors and concomitant diseases. The amputation patients have comparatively shorter survival time after operation, and amputation level is one of factors influencing the survival time.