Exercise can help prevent and treat all of the sedentary chronic diseases such as cancer, diabetes and cardiovascular disease. This may be due to endocrine and paracrine functions of skeletal muscles. Contracted muscles can release some hormones-like myokines, such as interleukin-6 (IL-6), IL-15, brain-derived neurotrophic factor (BDNF) and others. These myokines play roles in organ cross talk, including interactive adjustment among body organs, muscle and fat. Some myokines exert endocrine function, regulate the oxidation of visceral fat or mediate direct anti-inflammatory effects. While, other myokines play roles in fat oxidation-related signal pathway within the skeletal muscles through paracrine mechanism.