Objective To investigate the features of coronary artery lesions in the patients suffering from coronary artery disease (CAD) and connective tissue disease (CTD) and their long-term prognosis after percutaneous coronary intervention (PCI). Methods A consecutive series of 106 CTD patients who underwent PCI with stent implantation in our hospital between January 2009 and December 2012 were enrolled in this study. After their medical records were collected, the clinical manifestations and coronary artery lesions features were analyzed retrospectively. They were also followed-up for long-term incidences of major adverse cardiac events (MACE) . Results Ninety-two of the patients (86.8%) had one or more traditional CAD risk factors. Multi-vessel disease was present in the 78(73.6%) patients, with the left anterior descending coronary artery mostly involved (accounting for 65.1%). There were totally 5 bare-metal stents and 202 drug eluting stents implanted. During the follow-up of average 3 years, 24 cases (22.6%) of MACEs were observed, including 13(12.3%) death from cardiac causes, 10(9.4%) of stent thrombosis, and 15(14.2%) of target vessel revascularization (TVR). Conclusion Patients with CTD and CAD are characterized by multi-vessel lesions. Stent thrombosis and TVR are common adverse events in the patients after PCI.