Gout is one of the most common forms of arthritis, and its prevalence is gradually increasing. Improper treatment for the disease may lead to chronic pain, renal insufficiency, joint destruction and deformities, and thus, affect the quality of life in the patients. The main drugs for the treatment consist of those controlling the symptoms for acute gout and those managing hyperuricemia. Based on our experiences and clinical guidelines for gout at home and abroad, we reviewed the efficiency, safety and rational use of gout drugs.