Angiogenesis is characterized by forming new blood vessels from existing capillaries, and is mutually regulated by angiogenic factors and antiangiogenic factors in a dynamically balanced process. As a severely debilitating pathological change of a variety of diseases, including tumor, retinopathy of prematurity and diabetic retinopathy, etc, angiogenesis is a severely disabling condition. Thus, establishing animal models of neovascularization is an important prerequisite to study the pathogenesis. This article reviewed 4 animal models of angiogenesis, that is, aortic ring assay, matrigel plug assay, oxygen-induced retinopathy and laser-induced choroidal neovascularization in animal models.