Objective To investigate the correlation of heart valve calcification with coronary atherosclerosis in the adults at the age of 50-70 years in order to provide early warning before the symptom appearance induced by atherosclerosis. Methods Totally 205 subjects who underwent coronary artery angiography or coronary computed tomographic angiography (CTA) in our hospital from January 2010 to June 2015 were recruited in this study. According to the results of echocardiography, they were divided into calcification group (n=107) and non-calcification group (n=98). The blood pressure, blood glucose level and lipid profiles were measured and compared between the 2 groups. The correlations of the incidence of coronary heart disease and severity of coronary artery lesions were analyzed with heart valve calcification. Results The patients in calcification group had significantly higher incidences of hypertension, diabetes and hyperlipemia than those of non-calcification group (P<0.05). Except for high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and fasting plasma glucose were obviously higher in calcification group than in non-calcification group (P<0.05). The incidence of coronary artery disease was 64.49% in calcification group, with 42.99% of single vessel, 13.08% of 2 vessels, and 8.41% of ≥ 3 vessels of coronary artery lesions. However, in non-calcification group, the incidence of coronary artery disease was only 17.35%, and most of them were single vessel lesion. Both the incidence of coronary artery disease and the involved vessels of coronary artery lesions were remarkably higher in calcification group than in non-calcification group (P<0.05). ConclusionHeart valve calcification and coronary artery lesions are correlated. Investigation of heart valve calcification is an easy, fast and effective method to screen the patients needing for CTA or coronary artery angiography.