Objective To determine the feasibility and efficacy of endovascular treatment for atherosclerosis obliterans (ASO) of lower extremity. Methods Clinical data of 132 patients (136 limbs) with ASO of lower extremity undergoing endovascular treatment in the Department of Vascular Surgery of Baoding Second Hospital from June 2009 to June 2013 were collected. The endovascular treatment techniques, perioperative characteristics, clinical outcome, complications and follow-up results were analyzed. Results Our technical success rate was 98.5%(134/136), the incidence of complications was 5.15%(7/136), and no peri-operative death was observed in the cohort. The ankle-brachial index (ABI) was increased from 0.45±0.13 pre-operatively to 0.84±0.15 after treatment (P＜0.001). The primary patency rates were 93.28%(125/134), 88.06%(118/134) and 65.91%(91/132) at 6, 12 and 24 months, respectively. The secondary patency rates were 92.54%(124/134) and 68.94%(91/132) at 12 and 24 months, respectively. The limb salvage rate was 100.00%(132/132) at 24 months after surgery. Conclusion Endovascular treatment is an approach of high success rate and few complication for ASO of lower extremity.