Objective To evaluate the clinical safety and efficiency of endovascular treatment for subclavian artery stenosis or occlusion. Methods Totally 38 patients suffering from symptomatic subclavian artery stenosis or occlusion in our department from January 2011 to August 2015 were recruited in this study. They were 27 males and 11 females, at a mean age of (66.2±10.8) years. All of them presented the neurological symptoms such as dizziness, and some were accompanied by symptoms of upper limb ischemia. Percutaneous transluminal angioplasty and stent implantation were applied to them. Their clinical data and outcomes were collected and analyzed to evaluate the efficiency of the treatment. Results There were 36 cases successfully receiving balloon-expandable stent implantation. Their right- and left-arm blood pressure discrepancies were improved after treatment. The preoperative neurological symptoms were improved or disappeared in 33 patients after the procedures, but unchanged in 2 patients. Cerebral infarction occurred in 1 case during the interventional procedure, and the patient was recovered after thrombolysis and rehabilitation training. The operation did not succeed in 2 cases, and they were given conservative treatment. There were 3 patients having restenosis and 1 having stent fractured during the follow-up. Conclusion Under strict indications, endovascular intervention is safe, effective and easy to operate in the treatment of subclavian artery stenosis or occlusion with neurological symptoms.