Abstract:The complications of diabetes usually cause target organ damage, such as the heart, brain, kidneys and others, and are seriously hazardous to human health. But the underlying mechanism is still not very clear. Recent studies indicated that microRNA (miRNA) plays an important role in the occurrence and development of diabetes and its complications. miRNA, An endogenous small non-coding RNA molecule (containing about 22-25 nucleotides) in eukaryotes, regulates the expression of its downstream target genes at post-transcriptional level, and then influences the pathophysiology of diseases. Many studies have reported that miRNA-200 (miR-200) family plays certain regulative roles in diabetes and its complications. The family not only regulates insulin related signal pathway, but also plays an important role in diabetic microvascular and macrovascular complications. Therefore, to explore the relationship of miR-200 family with diabetes and its complications would provide a new train of thought for diagnosis and treatment of diabetes and its complications.