Both excess and deficiency of thyroid function are potentially deleterious to bone tissue. Overt hyperthyroidism leads to decrease in bone mineral density (BMD) and increasein risks for fracture. While, hypothyroidism probably leads to increased fracture risk too. Aging is a well-recognized risk factor of osteoporosis. So, it is necessary to control thyroid function to certain individual target during the treatment of thyroid disease in the elderly. In some cases, bisphosphonate or other agents should be indicated to prevent or treat osteoporosis.