Objective To evaluate the clinical efficiency of atorvastatin calcium in the treatment of senile cerebral arteriosclerosis. Methods A total of 124 elderly patients with cerebral arteriosclerosis admitted in our hospital from December 2012 to December 2014 were subjected in this study. They were randomly divided into test group and control group (n＝62). The control group was given conventional treatment, and the test group was administered by atorvastatin calcium besides of conventional treatment for 6 months. Blood lipids, intracranial artery elasticity index, size of carotid artery plaque and incidence of cerebrovascular diseases were measured and compared between the 2 groups. Results The blood lipids, intracranial artery elasticity index, and size of cerebral artery plaque were obviously improved in the 2 groups after treatment when compared with before the treatment (P＜0.05), and those in the test group were more significant than in the control group (P＜0.05). The total effective rate was 98.4% in the test group, remarkably higher than that of the control group (80.6%, χ2＝5.436, P＜0.05). The incidence of cerebrovascular disease was markedly lower in the test group than in the control group (3.2% vs 16.1%, χ2＝5.324, P＜0.05). Conclusion Atorvastatin calcium effectively attenuates the symptoms in the elderly patients with cerebral arteriosclerosis, and reduces the occurrences of cerebrovascular diseases.