Objective To retrospectively analyze the clinical features and summarize comprehensive treatment and outcome for postherpetic neuralgia (PHN) in the aged patients. Methods Clinical data of all hospitalized elderly patients with PHN admitted in our hospital between January 2013 and December 2014 were collected and retrospectively analyzed for the clinical features, treatment and outcome of the disease. Results A total of 39 PHN patients were enrolled in this study, and they were 26 males and 13 females, at an average age of (71.3±8.3) years, and 33 of them were older than 60 years. Most PHN (74.4%, 29 cases) presented on the chest/rib cage. Their visual analogue score (VAS) was 6.9±0.8 at the time of admission and then decreased to 2.9±0.7 when being discharged after comprehensive treatment including systemic medication and nerve block anesthesia. Long-term follow-up indicated that 21% patients obtained a reduction in pain by 90%, and 56% of them by 50% relief. Conclusion The elderly are high-risk population for PHN. Systemic medication and nerve block show therapeutic effect on the disease in the elderly.