In this article, we reported our successful treatment for a senile lymphoma patient (male, 98 years old) complicated by chylothorax. His initial symptoms were wheezing and trouble breathing at onset. We found he had left pleural effusion and enlarged left supraclavicular lymph nodes, and then he was diagnosed as chylothorax after thoracentesis and lymphoma by lymph node biopsy. After the lymphoma was treated by molecular target therapy and the chylothorax by dietetic treatment and pleurodesis, the left supraclavicular lymph nodes were significantly reduced, and the output of chylothorax was also decreased.