Objective Usually, ischemic colitis has a good outcome, but when ischemia only involves the right side of the colon, the prognosis may be not so favorable. This study aimed to compare the prognosis of ischemia only involving the right side of the colon with those of involving other segments of the colon. Methods A retrospective study was performed on the 170 patients with colon ischemia hospitalized during the interval of January 1999 to December 2010. They were divided into 2 groups: those with isolated right colon ischemia (IRCI) and those with colon ischemia except IRCI (non-IRCI). Only the patients with colonoscopy-confirmed ischemic colitis were entered into our study. Results A total of 170 cases were enrolled in this study, of which 36(21.18%) were IRCI patients. Of these IRCI cases, 61.11% had an unfavorable outcome even after treatment, but the percentage was only 8.96% for those with non-ICRI. Eighteen IRCI patients (50.00%) required surgical treatment, but only 7.46% of non-IRCI patients need. The mortality was 16.67% in patients with IRCI and only 1.49% in patients with non-IRCI (2 cases). Conclusion Among 170 cases of colonoscopy-confirmed ischemic colitis, 36 (21.18%) involve only the right side of the colon. The patients with IRCI have a worse outcome than those with colon ischemia involving other colon segments.