Objective To investigate senile degenerative heart valvular diseases (SDHVD) and multiple organ diseases. Methods A multi-center study was carried out in some sanatoriums for retired veteran cadres and their couples from October 2008 to June 2014. There were 3 896 elderly patients recruited (all with full medical records and undergoing overall physical examination every year), including 2 884 males and 1 012 females, with age of (78±13) years (ranging from 60 to 103 years). Clinical data of their echocardiography, physical examination, and auxiliary examination were collected and analyzed for multiple organ diseases. Results Among the 3 896 elderly patients, there were 1 225 having SDHVD (31.4%). The incidences of multiple organ diseases in the SDHVD group and non-SDHVD group were as follows respectively: hypertension 49.3% vs 28.4%, coronary heart disease 38.5% vs 23.8%, heart failure 36.2% vs 17.3%, pulmonary heart disease 6.3% vs 3.1%, stroke 21.6% vs 9.6%, renal insufficiency 6.9% vs 3.2%, gastroesophageal reflux disease 21.3% vs 10.3%, and diabetes mellitus 11.2% vs 12.1%. Significant differences were found in all above incidences except for that of diabetes mellitus between the 2 groups (P＜0.05). Conclusion Multiple organ diseases are more common in the elderly suffering from SDHVD. It might be due to that SDHVD induces cardiac remodeling and abnormal hemodynamics, and thus triggers the occurrence and development of multiple organ diseases.