老年人高同型半胱氨酸高血压与血尿酸、纤维蛋白原的关系
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Correlation of H-type hypertension with serum uric acid and fibrinogen in the elderly
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    摘要:

    目的 探讨老年人高同型半胱氨酸(Hcy)高血压(H型高血压)与血尿酸(UA)、纤维蛋白原(FIB)水平的关系。方法 选择2013年1月至2014年1月在石河子大学医学院第一附属医院老年病科门诊及病房收治的老年原发性高血压患者251例,其中Hcy水平≥15μmol/L为老年H型高血压组121例,Hcy水平<15μmol/L为单纯高血压组130例;另外同期选择老年健康体检患者150例为对照组。同期测定Hcy、UA、FIB水平,比较各组UA、FIB水平的差异。结果 老年H型高血压组、单纯高血压组、与对照组3组UA[(320.97±106.61)、(280.74±71.27)与(261.01±71.80)μmol/L]及FIB[(3.22±0.52)、(3.05±0.52)与(2.68±0.41)g/L]两两比较差异均有统计学意义(P<0.01);logistic回归分析结果示,H型高血压与UA(OR=3.896)、FIB(OR=3.100)水平及叶酸降低水平(OR=2.776)成正比(P<0.05)。结论 老年H型高血压与UA、FIB密切相关。监测UA及FIB对老年H型高血压的管理具有重要意义。

    Abstract:

    Objective To investigate the correlation of high homocysteine (Hcy) hypertension (H-type hypertension) with serum levels of uric acid (UA) and fibrinogen (FIB) in the elderly. Methods A total of 251 elderly in- and out-patients with essential hypertension admitted in our department from January 2013 to January 2014 were recruited in this study. They were divided into H-type hypertension group [n=121, serum Hcy level ≥15μmol/L] and primary hypertension group (n=130, serum Hcy level<15μmol/L). Another 150 elderly individuals without hypertension taking physical examination in our hospital during same period served as controls. Serum levels of Hcy, UA and FIB were detected in all the patients, and the results were compared among different groups. Results For the H-type hypertension, primary hypertension and control groups, there were statistical differences in the levels of UA [(320.97±106.61), (280.74±71.27) and (261.01±71.80μmol/L)] and FIB [(3.22±0.52), (3.05±0.52) and (2.68±0.41)g/L] between any of the 2 groups (P<0.01). Logistic regression analysis showed that H-type hypertension was positively correlated with the serum level of UA (OR=3.896) and FIB (OR=3.100) and with the reduced level of folic acid (OR=2.776, all P<0.05). Conclusion H-type hypertension is closely associated with UA and FIB. Monitoring their levels is of great significance in the management of H-type hypertension in the elderly.

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高银凤,柳 达*,罗文利,王 婧.老年人高同型半胱氨酸高血压与血尿酸、纤维蛋白原的关系[J].中华老年多器官疾病杂志,2014,13(08):587~590

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  • 在线发布日期: 2014-08-22
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