Objective To determine the correlation of serum uric acid (SUA) level with diabetic peripheral neuropathy (DPN) in the patients with type 2 diabetes mellitus (T2DM). Methods A total of 920 T2DM in- and out-patients in our department from March 2011 to March 2013 were enrolled in this cross-sectional study. Biochemical parameters, such as fasting blood glucose (FBG), glycosylated hemoglobin Alc (HbAlc), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and SUA were measured. DPN was diagnosed by neuropathy symptom score and neuropathy disability score. The subjects were stratified according to quartiles of SUA levels. Logistic regression analysis was used to analyze odds ratios between SUA and the prevalence of DPN. Results The adjusted logistic regression indicated that the level of SUA was a risk factor of DPN after 2nd quartile (＞3.5mg/dl); and with the increase in the level, its effect on prevalence of DPN from 2nd to 4th quartiles became more significant [OR=2.95 (2.02 to 8.76), 3.06 (1.75 to 6.45), and 4.15 (0.84 to 6.74), P＜0.05]. Conclusion Level of SUA is a risk factor for the prevalence of DNP in T2DM patients. In the clinical management of DPN, monitoring SUA should be one of important treatment in addition to controlling glucose and lowering blood pressure.