Objective To determine the efficacy of small doses of levamlodipine, telmisartan and hydrochlorothiazide given at the same or different time points on anti-hypertension and reverse of non dipper hypertension. Methods Three hundred over-45-year-old patients with non-dipper hypertension [systolic blood pressure (SBP) ＜180mmHg and diastolic blood pressure (DBP) ranging from 90 to 109mmHg)] admitted in our out- and in-patient departments from May 2011 to October 2013 were prospectively subjected in this study. They were randomly divided into 2 groups, group Ⅰ (the drugs were given at different time, 40mg telmisartan and 10mg hydrochlorothiazide were given in the morning, while 2.5mg levamlodipine at night), and group Ⅱ (all 3 drugs were given at the morning). All cases received ambulatory blood pressure monitoring before and in 8 weeks after treatment. Results In 8 weeks after the treatment, the 24-hour SBP/DBP was reduced by 14.92/9.96mmHg and 15.04/10.66mmHg respectively for groups Ⅰ and Ⅱ, while the daytime SBP/DBP was decreased by 13.90/10.60mmHg and 16.06/11.70mmHg, respectively. These indices were all significantly lower than before treatment (P＜0.01), but there was no difference between the 2 groups (P＞0.05). The nighttime SBP/DBP was reduced by 25.44/19.48mmHg in group Ⅰ and by 17.68/14.76mmHg in group Ⅱ, and both were significantly lower than before treatment (P＜0.01, P＜0.05). The reversion of non-dipper hypertension was 88.16% and 55.41% for the 2 groups, with significant difference between them (P＜0.01). Conclusion No matter small doses of levamlodipine, telmisartan and hydrochlorothiazide are given at the same or different time points, they effectively control the 24-hour and daytime blood pressures. But the drugs given at different time points can reverse non-dipper hypertension better.