老年高血压患者夜间血压模式短期可重复性的临床研究
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Short-term reproducibility of nocturnal blood pressure pattern in elderly essential hypertensive patients
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    摘要:

    目的 通过分析老年高血压患者动态血压监测(ABPM)夜间血压模式的可重复性,评估其在临床应用中的实际意义。方法 对入住上海交通大学附属第六人民医院老年科70名老年高血压患者[男45例,女25例,年龄(83.57±5.37)岁]于4周内进行两次24hABPM,根据夜间血压下降率分为杓型(D)、非杓型(ND)、反杓型(RD)3种血压模式,把夜间下降率分别作为连续性变量和分类变量来分析血压模式的短期可重复性,并探究可重复的不同模式间的差异。结果 作为连续性变量,Bland-Altman图示夜间下降率可重复性较好;作为分类变量,第2次ABPM维持原来血压模式不变的受试者共占65.7%(46/70),其中50.0%(14/28)维持原来RD,76.5%(13/17)维持原来D,76.0%(19/25)维持原来ND,kappa值为0.482。第1次ABPM为RD、D和ND在第2次ABPM转变为其他模式的分别有20.0%,5.7%和8.6%。可重复的RD(组1)、D(组2)、ND(组3)与模式变换型(组4)两两之间比较的主要临床特点无明显差异。结论 老年高血压患者的夜间血压模式无论是作为分类变量还是连续变量,可重复性都尚好,且RD血压模式相比D或ND的变异性更高,因此,临床上我们不可以仅凭一次ABPM就评定患者的血压模式。本研究尚未发现可能影响血压模式重复性的因素。

    Abstract:

    Objective To analyze the reproducibility of nocturnal blood pressure pattern in the elderly hypertensive patients by ambulatory blood pressure monitoring (ABPM) and evaluate its significance in clinical practice. Methods A total of 70 elderly essential hypertensive patients [45 males and 25 females, aged (83.57±5.37) years] admitted in the Department of Geriatrics from the Sixth People’s Hospital of Shanghai Jiaotong University were enrolled in this study. They underwent ABPM over two 24-hour periods within 4 weeks and other routine examinations. Their dipping patterns were classified as dippers (D), non-dippers (ND) and reverse-dipper (RD) according to their average systolic blood pressure at night compared to daytime. The short-term reproducibility was evaluated when above 3 different patterns used as continuous variables or categorical variables, and the differences among the reproducible and variable modes were analyzed. Results When the dipping patterns used as continuous variables, Bland-Altman’s plot showed that the reproducibility was good. While as categorical variables, overall 65.7% of the total 70 subjects (46/70) showed consistent dipping pattern during the 2 periods of ABPM, including 50.0% (14/28) confirming the identical RD, 76.5% (13/17) the identical D, and 76.0% (19/25) the identical ND (kappa=0.482). Subjects who had RD, D and ND on the first ABPM but changed to another pattern on the second time accounted for 20.0%, 5.7%, and 8.6%, respectively. No significant difference was found among the persistent RD (group 1), D (group 2), ND (group 3) and those with variable dippers (group 4) in main clinical characteristics. Conclusion The nocturnal blood pressure pattern is moderately reproducible in the elderly hypertensive patients, regardless of as continuous or categorical variable, but the reverse-dippers have higher variability when compared to dippers and non-dippers. Therefore, we should not confirm the dipping status based on single period of ABPM. This study has not found any factor that may affect the noctunal dipping pattern.

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高聪聪,王蓓芸,黄高忠.老年高血压患者夜间血压模式短期可重复性的临床研究[J].中华老年多器官疾病杂志,2014,13(03):210~214

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  • 在线发布日期: 2014-04-02
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