Objective To investigate the safety of transurethral 2-micron laser used to prostatic surgery in advanced aged patients(＞65 years). Methods A total of 114 males and 23 females with a median age of 71 years (ranging from 65 to 87 years) receiving transurethral surgery in our department from September 2010 to October 2012 were enrolled in this study. There were 83 males with benign prostatic hyperplasia (BPH) and 31 with non-muscle bladder cancer(BCa), and all 23 females suffered from BCa. There were 121 cases(88.3%) with comorbidity, and 85 cases having over two diseases. Selective transurethral resection by 2-micron laser was performed after judging the function of important organs. Operation time, duration of indwelling urethral catheter, obturator nerve reflex, bladder washing, urination after BPH surgery, and peri-operative complications were analyzed. Results All operation procedures were successfully carried out. The mean operaton time was 30min(ranging from 15 to 55min) for BCa and 65min(ranging from 35 to 130min) for BPH, respectively. Bladder washing was taken, and time for indwelling urethral catheter ranged from 5 to 7d. Post-operative complications occurred in 11 cases(8.03%), and they were all discharged after corresponding treatment. There was no death in the cohort of patients. Conclusion Transurethral resection by 2-micron laser is an approach with satisfactory outcome and minimal invasion, and is of high safety for advanced aged who needs surgical treatment but suffers from comorbidity.