Abstract:Objective To investigate the pre-operative serum levels of glycosylated products in the elderly type 2 diabetes mellitus patients with stable angina undergoing selective percutaneous coronary intervention(PCI), and evaluate the relationship between the levels and short-term outcomes. Methods A total of 188 elderly patients with diabetes and stable angina who were treated with PCI in our hospital from January 2010 to December 2012 were consecutively enrolled in this study. The patients were divided into 2 groups according to onset of post-procedure outcome events, the control group(no event) and the event group(ischemic events: post-procedure angina, myocardial infarction and death). The profiles of clinical cardiovascular risk factors, levels of fasting blood glucose, glycosylated products [glycosylated hemoglobin A1c(HbA1c) and glycosylated serum protein(GSP)] and high sensitivity C reactive protein(hs-CRP) were collected before PCI and compared between 2 groups. Results There was no significant difference in the age, gender, body mass index, history of smoking, incidences of hypertension and hyperlipidemia, medication, and serum HbA1c level between 2 groups(P>0.05). However, the patients in event group had significantly higher levels of fasting blood glucose, GSP and hs-CRP than those in control group(P<0.01). The risk of complicating post-procedure ischemic events in the patients with higher GSP levels(>220μmol/L) was much higher than that in patients having lower GSP levels(OR=2.96, 95% CI=1.50-5.81, P=0.001). Conclusion Elevated GSP level before PCI may be a risk factor of post-procedure ischemic events in the elderly patients with diabetes and stable angina undergoing selective PCI.